Codexis研發新的診斷酶
2017年1月6日：世界領先的生物催化酶開發供應者Codexis宣布公司將會提供使用下一代測序 （NGS）和PCR的體外診斷的客戶提供高性能酶。Codexis的首個專利酶是用于該市場幫助NGS使用者提高文庫構建的，預計在2017年第二季度進入實驗。
Gingko Bioworks收購Gen9
2017年1月20日：Ginkgo Bioworks宣布收購合成DNA提供者Gen9，但并沒有披露價格。Gingko
將為多個行業的運用，提高其對新型有機體設計的速度和能力。本次收購將使Gen9從組裝合成DNA
專家轉變為自動化生物工程的鑄造工廠。
c-LEcta接手Denarase?市場和分銷
2017年1月26日：一家德國萊比錫的工業生物技術公司c-LEcta宣布2016年底該公司已從
Sartorius Stedim GmbH接手了Denarase?的分銷。Denarase?是一種來自于粘質沙雷氏菌
（Serratia marcescens）的基因工程核酸內切酶，能夠非常有效地切割所有形式的DNA和RNA，是
生物技術中常用的定量去除核酸和降低粘度的酶。
諾維信贏得中國專利案件
2017年2月17日：經過曠日持久的官司，諾維信贏得了兩個中國企業專利侵權案件。中國最高
人民法院決定審判諾維信與山東龍達生物制品有限公司（Longda Bio-Products Co.）和江蘇生物
產品有限公司（Jiangsu Bioproducts Co.）的案件勝訴。諾維信在2013年的時候控告這兩家公司
侵犯了其一個糖化酶的專利，可獲得170萬人民幣的賠償。但這兩家公司進行了上訴并且質疑諾維
信專利的有效性。通過幾個級別的法院，最后到達了中國最高人民法院，決定堅持諾維信專利的有
效性。這是最終裁決，不能上訴。
會議預告
1）2017年3月6日-8日，有機過程的研究和開發，帕薩迪納，美國；
https://scientificupdate.co.uk/index.php/conferences/conferences-and-
workshops/details/297-Organic-Process-Research-and-Development-Europe.html
2）2017年5月16日-18日Informex貿易展覽和會議，賓夕法尼亞州費城，美國；
3）2017年7月9日-13日，Biotrans 2017，匈牙利布達佩斯；
最新發表文獻摘選：
Expression of a codon-optimized β-glucosidase from Cellulomonas
flavigena PR-22 in Saccharomyces cerevisiae for bioethanol production from cellobiose.
Ríos-Fránquez FJ, González-Bautista E, Ponce-Noyola T, Ramos-Valdivia AC, Poggi-Varaldo HM, García-Mena
J, Martinez A. Arch Microbiol. 2017 Jan 30. doi: 10.1007/s00203-016-1333-2. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28138738
Converting Pasteurella multocida α2-3-sialyltransferase 1 (PmST1) to a
regioselective α2-6-sialyltransferase by saturation mutagenesis and
regioselective screening.
McArthur JB, Yu H, Zeng J, Chen X. Org Biomol Chem. 2017 Jan 30. doi:
10.1039/c6ob02702d. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28134951
Stereoselective biotransformation of racemic mandelic acid using
immobilized laccase and (S)-mandelate dehydrogenase.
Chen X, Yang C, Wang P, Zhang X, Bao B, Li D, Shi R. Bioresour Bioprocess. 2017;4
(1):2. doi: 10.1186/s40643-016-0135-3.
https://www.ncbi.nlm.nih.gov/pubmed/28133593
Biosynthesis of enantiopure (S)-3-hydroxybutyrate from glucose through
the inverted fatty acid β-oxidation pathway by metabolically engineered
Escherichia coli.
Gulevicha AY, Skorokhodovaa AY, Sukhozhenkoa AV, Debabova VG. J Biotechnol. 2017 Jan
25. pii: S0168-1656(17)30026-3. doi: 10.1016/j.jbiotec.2017.01.009. [Epub ahead of
print]
https://www.ncbi.nlm.nih.gov/pubmed/28131860
Production and Characterization of Organic Solvent-Tolerant Cellulase
from Bacillus amyloliquefaciens AK9 Isolated from Hot Spring.
Irfan M, Tayyab A, Hasan F, Khan S, Badshah M, Shah AA. Appl Biochem Biotechnol. 2017
Jan 27. doi: 10.1007/s12010-017-2405-8. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28130767
Structural and biochemical studies of novel aldo-keto reductases for the
biocatalytic conversion of 3-hydroxybutanal to 1,3-butanediol.
Kim T, Flick R, Brunzelle J, Singer A, Evdokimova E, Brown G, Joo JC, Minasov GA,
Anderson WF, Mahadevan R, Savchenko A, Yakunin AF. Appl Environ Microbiol. 2017 Jan
27. pii: AEM.03172-16. doi: 10.1128/AEM.03172-16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28130301
Identification and characterization of a novel N-acyl-homoserine
lactonase gene in Sphingomonas ursincola isolated from industrial
cooling water systems.
Morohoshi T, Sato N, Iizumi T, Tanaka A, Ikeda T. J Biosci Bioeng. 2017 Jan 24. pii:
S1389-1723(16)30350-4. doi: 10.1016/j.jbiosc.2016.12.010. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28129983
Specificity and mechanism of mandelamide hydrolase catalysis.
Adediran SA, Wang PF, Shilabin AG, Baron CA, McLeish MJ, R F Pratt. Arch Biochem
Biophys. 2017 Jan 24. pii: S0003-9861(16)30577-X. doi: 10.1016/j.abb.2017.01.010.
[Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28129982
Different specificities of two aldehyde dehydrogenases from
Saccharomyces cerevisiae var boulardii.
Datta S, Annapore US, Timson DJ. Biosci Rep. 2017 Jan 26. pii: BSR20160529. doi:
10.1042/BSR20160529. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28126723
Crystal Structure and Functional Characterization of an Esterase (EaEST)
from Exiguobacterium antarcticum.
Lee CW, Kwon S, Park SH, Kim BY, Yoo W, Ryu BH, Kim HW, Shin SC, Kim S, Park H, Kim
TD, Lee JH. PLoS One. 2017 Jan 26;12(1):e0169540. doi: 10.1371/journal.pone.0169540.
https://www.ncbi.nlm.nih.gov/pubmed/28125606
ANCUT2, a Thermo-alkaline Cutinase from Aspergillus nidulans and Its
Potential Applications.
Bermúdez-García E, Pe?a-Montes C, Castro-Rodríguez JA, González-Canto A, Navarro-Oca?
a A, Farrés A. Appl Biochem Biotechnol. 2017 Jan 25. doi: 10.1007/s12010-016-2378-z.
[Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28124733
Heterologous expression and enzymatic characterization of γ-
glutamyltranspeptidase from Bacillus amyloliquefaciens.
Lee JM, Lee J, Nam GH, Son BS, Jang MU, Lee SW, Hurh BS, Kim TJ. J Microbiol. 2017
Feb;55(2):147-152. doi: 10.1007/s12275-017-6638-6.
https://www.ncbi.nlm.nih.gov/pubmed/28120195
A bacterial GH6 cellobiohydrolase with a novel modular structure.
Cerda-Mejía L, Valenzuela SV, Frías C, Diaz P, Pastor FI. Appl Microbiol Biotechnol.
2017 Jan 25. doi: 10.1007/s00253-017-8129-4. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28120014
Engineering 7?-Hydroxysteroid Dehydrogenase for Enhanced Ursodeoxycholic
Acid Production by Multiobjective Directed Evolution.
Zheng MM, Chen KC, Wang RF, Li H, Li CX, Xu JH. J Agric Food Chem. 2017 Feb 3. doi:
10.1021/acs.jafc.6b05428. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28116898
Catechol Removal from Aqueous Media Using Laccase Immobilized in
Different Macro- and Microreactor Systems.
Tu?ek AJ, ?ali? A, Zeli? B. Appl Biochem Biotechnol. 2017 Jan 23. doi:
10.1007/s12010-017-2419-2. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28116574
Biodegradation of polycyclic aromatic hydrocarbons (PAHs) by fungal
enzymes: A review.
Kadri T, Rouissi T, Kaur Brar S, Cledon M, Sarma S, Verma M. J Environ Sci (China).
2017 Jan;51:52-74. doi: 10.1016/j.jes.2016.08.023. Review.
https://www.ncbi.nlm.nih.gov/pubmed/28115152
Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid
biosynthesis.
Zou Y, Garcia-Borràs M, Tang MC, Hirayama Y, Li DH, Li L, Watanabe K, Houk KN, Tang
Y. Nat Chem Biol. 2017 Jan 23. doi: 10.1038/nchembio.2283. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28114276
A novel thermophilic and halophilic esterase from Janibacter sp. R02,
the first member of a new lipase family (Family XVII).
Castilla A, Panizza P, Rodríguez D, Bonino L, Díaz P, Irazoqui G, Rodríguez Giordano
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https://www.ncbi.nlm.nih.gov/pubmed/28110668
Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and
Mechanistically Diverse.
Agarwal V, Miles ZD, Winter JM, Eustáquio AS, El Gamal AA, Moore BS. Chem Rev. 2017
Jan 20. doi: 10.1021/acs.chemrev.6b00571. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28106994
A peroxygenase from Chaetomium globosum catalyzes the selective
oxygenation of testosterone.
Kiebist J, Schmidtke KU, Zimmermann J, Kellner H, Jehmlich N, Ullrich R, Z盲nder D,
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https://www.ncbi.nlm.nih.gov/pubmed/28103392
A Novel Multi-domain High Molecular, Salt-Stable Alkaline Xylanase from
Alkalibacterium sp. SL3.
Wang G, Wu J, Yan R, Lin J, Ye X. Front Microbiol. 2017 Jan 4;7:2120. doi:
10.3389/fmicb.2016.02120.
https://www.ncbi.nlm.nih.gov/pubmed/28101084
An overview of aldehyde oxidase: an enzyme of emerging importance in
novel drug discovery.
Rashidi MR, Soltani S. Expert Opin Drug Discov. 2017 Jan 17. doi:
10.1080/17460441.2017.1284198. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28095715
Transferase Versus Hydrolase: The Role of Conformational Flexibility in
Reaction Specificity.
Light SH, Cahoon LA, Mahasenan KV, Lee M, Boggess B, Halavaty AS, Mobashery S,
Freitag NE, Anderson WF. Structure. 2017 Jan 5. pii: S0969-2126(16)30397-5. doi:
10.1016/j.str.2016.12.007. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28089449
Identification and characterization of L-lysine decarboxylase from
Huperzia serrata and its role in the metabolic pathway of lycopodium
alkaloid.
Xu B, Lei L, Zhu X, Zhou Y, Xiao Y. Phytochemistry. 2017 Jan 12. pii: S0031-9422(16)
30307-7. doi: 10.1016/j.phytochem.2016.12.022. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28089246
Xenobiology meets enzymology: Exploring the potential of unnatural
building blocks in biocatalysis.
Budisa N, V枚ller JS, Koksch B, Acevedo-Rocha CG, Kubyshkin V, Agostini F. Angew Chem
Int Ed Engl. 2017 Jan 13. doi: 10.1002/anie.201610129. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28085996
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